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Records 26 to
50
of 7363
2024
New approach methods for developmental neurotoxicity: a per- and polyfluoroalkyl substances (PFAS) case study
(PRESENTATION) [Presented : Mar 21, 2024]
(PRESENTATION) [Presented : Mar 21, 2024]
Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research
By-degree Health and Economic Impacts of Lyme Disease, Eastern and Midwestern United States
(JOURNAL) [Published : Mar 13, 2024]
(JOURNAL) [Published : Mar 13, 2024]
Journal article submitted to EcoHealth - (Abstract) - Lyme disease (LD) is the most common vector-borne disease in the United States (U.S.). This paper assesses how climate change may influence LD incidence in the eastern and upper midwestern U.S., and the associated economic bur...
Methods to Identify Hazards in Produced Water
(PRESENTATION) [Presented : Apr 05, 2024]
(PRESENTATION) [Presented : Apr 05, 2024]
This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.
Trimethylbenzenes - Encyclopedia of Toxicology chapter
(BOOK CHAPTER) [Published : Apr 14, 2014]
(BOOK CHAPTER) [Published : Apr 14, 2014]
Trimethylbenzene (TMB; CAS 25551-13-7) is a commercially available mixture of three individual isomers: 1,2,4-, 1,2,3-, and 1,3,5-TMB. TMB isomers are produced during petroleum refining. TMB exposure in humans occurs primarily through inhalation, although ingestion of TMB isomers...
In vitro mobilization of polychlorinated biphenyls and pesticides sorbed to ingested soils and house dusts
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and PurposeSoil and dust are effective sorbents for many organic chemicals and are known to concentrate lipophilic, less volatile, environmental pollutants. For children’s risk assessment, this is important, primarily because children consume relatively large qua...
Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (Syngenta SOT 24)
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose:
Limitations to the in vivo developmental neurotoxicity (DNT) test includes high variability, low reproducibility, and unknown human relevance. Moreover, neuropathological assessments in the DNT guideline are challenging due to methodology, lack of mecha...
Arsenic, cadmium, lead, antimony bioaccessibility and relative bioavailability in legacy gold mining waste
(JOURNAL) [Published : May 05, 2024]
(JOURNAL) [Published : May 05, 2024]
Bioaccessibility and relative bioavailability of As, Cd, Pb and Sb was investigated in 30 legacy gold mining wastes (calcine sands, grey battery sands, tailings) from Victorian goldfields (Australia). Pseudo-total As concentration in 29 samples was 1.45–148-fold higher than...
US experience for NAM Implementation for DNT
(PRESENTATION) [Presented : Apr 10, 2024]
(PRESENTATION) [Presented : Apr 10, 2024]
Presentation to the 5th International Conference on Developmental Neurotoxicity Testing (DNT5) April 2024
Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways using Omics Approaches
(PRESENTATION) [Presented : Apr 10, 2024]
(PRESENTATION) [Presented : Apr 10, 2024]
Development of in vitro new approach methodologies (NAMs) has been driven by the need for developmental neurotoxicity (DNT) hazard data on thousands of chemicals. The network formation assay (NFA) characterizes DNT hazard based on changes in network formation but provides no mech...
Identification of training set chemicals to demonstrate the transferability of the developmental neurotoxicity in vitro battery
(PRESENTATION) [Presented : Apr 10, 2024]
(PRESENTATION) [Presented : Apr 10, 2024]
The developmental neurotoxicity (DNT) in vitro battery (IVB) is a group of new approach methods for evaluation of potential compound effects on fundamental neurodevelopmental processes. These assays were developed to enhance efficiency of chemical screening and prioritization rel...
Sulfonamide PFAS cause developmental abnormalities in mummichogs (Fundulus heteroclitus)
(PRESENTATION) [Presented : Apr 12, 2024]
(PRESENTATION) [Presented : Apr 12, 2024]
Per- and polyfluoroalkyl substances (PFAS) are long-lasting environmental contaminants with known adverse impacts on fish and other taxa. However, understanding of their impacts on coastal environments, including the effect of chemical structure on toxicity in estuarine and marin...
Computational Systems Models for Neurovascular Development
(PRESENTATION) [Presented : Apr 10, 2024]
(PRESENTATION) [Presented : Apr 10, 2024]
Computational Systems Models for Neurovascular Development
Thomas B. Knudsen, Research Triangle Park, NC
Morphogenesis of the blood-brain barrier (BBB) is a complex process linked to neovascularization of the embryonic neural tube. This selective transport interface forms...
Using early life stage assays to assess impact of a suite of diverse PFAS exposures in the mummichog (Fundulus heteroclitus)
(PRESENTATION) [Presented : Apr 12, 2024]
(PRESENTATION) [Presented : Apr 12, 2024]
Per- and polyfluoroalkyl substances (PFAS) are widely used, long-lasting environmental contaminants linked to adverse effects in fish and other species. There are thousands of unique PFAS that are likely to impact organisms in different ways and through different mechanisms. The ...
Assessing lead exposure in U.S. pregnant women using biological and residential measurements
(JOURNAL) [Published : Sep 21, 2023]
(JOURNAL) [Published : Sep 21, 2023]
There is strong scientific evidence for multiple pathways of human exposure to lead (Pb) in residential settings, particularly for young children; however, less is known about maternal exposure during pregnancy and children’s exposure during early lifestages. A robust, mult...
EPA Children's Environmental Health Research Centers
(PRESENTATION) [Presented : Mar 20, 2024]
(PRESENTATION) [Presented : Mar 20, 2024]
This is a short presentation to the Subcommittee on Chemical Exposures of the President's Task Force on Environmental Health Risks and Safety Risks to Children. The presentation briefly touches on the STAR program history of ORD funding for Children's Centers, and discusses our c...
SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Environmental justice seeks to affirm individual’s rights to a healthy environment within communities that are subjected to a disproportionate burden of environmental hazard. These communities often experience higher levels of chronic stress and reduced quality of life, whi...
Evaluating two analysis methods for the microelectrode array network formation assay
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...
New Approach Methodology for Developmental Neurotoxicity: Past, Present and Future
(PRESENTATION) [Presented : Mar 22, 2024]
(PRESENTATION) [Presented : Mar 22, 2024]
Topics covered: Brief History of the EPA and Regulatory Statutes; Need for Alternative Approaches for Neurotoxicity and Developmental Neurotoxicity Hazard Assessment; Brief History of NAMs for DNT; Examples of How DNT NAMs are being utilized for decision-making; Informing AOP Dev...
Exploring maternal and developmental toxicity of PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics presentation
(PRESENTATION) [Presented : Mar 22, 2024]
(PRESENTATION) [Presented : Mar 22, 2024]
These data were recently presented at SOT 2024 as a poster, and this sub-product will present the same data and analyses in a presentation at a local society meeting of endocrine disrupting chemicals NC (EDC-NC). Sprague-Dawley rat dams were exposed via oral gavage from GD18-22 t...
Re-testing of false negative compounds in new approach methods (NAMs) for developmental neurotoxicity screening
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose: Recently, the Organization of Economic Cooperation and Development (OECD) published an “Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity In Vitro Testing Battery (DNT-IVB)” that describes a battery of 17 in vit...
US EPA’s Report on the Environment (ROE)--Overview and Website demonstration
(PRESENTATION) [Presented : Apr 04, 2024]
(PRESENTATION) [Presented : Apr 04, 2024]
EPA’s Report on the Environment (ROE) brings together the most reliable and readily available indicators to create a comprehensive view of the nation’s environmental and human health status and trends. The indicators provide an objective basis for Agency decision maki...
High-throughput Identification of Androgen Disrupting ToxCast Chemicals and CYP450 Metabolites
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose
The identification of chemicals with the potential to disrupt androgen signaling is a key component of the EPA’s Endocrine Disruption Screening Program (EDSP). EPA researchers have worked to devise in vitro assays and computational models to serve as ...
Residential greenness, asthma, and lung function among children at high risk of allergic sensitization: a prospective cohort study
(JOURNAL) [Published : May 12, 2022]
(JOURNAL) [Published : May 12, 2022]
Background: While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent.
Methods: We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quan...
Maternal exposure to nitrosamines in drinking water during pregnancy and birth outcomes in a Chinese cohort
(JOURNAL) [Published : Jan 06, 2023]
(JOURNAL) [Published : Jan 06, 2023]
Maternal exposure to regulated disinfection by-products (DBPs) during pregnancy has been linked with adverse birth outcomes. However, no human studies have focused on drinking water nitrosamines, a group of emerging unregulated nitrogenous DBPs that exhibits genotoxicity and deve...